Project Description
Currently I am undertaking an animal model of inflammatory bowel disease study using Muc2 KO mice. These mice lack a mucus layer and therefore develop spontanous colitis by 12-16 weeks of age. We are feeding these mice either a fermentable fibre free or prebiotic enriched diet to determine what impact fibre has on the development of sponanteous colitis and understand the mechanisms of action involved.
Research Interests
- Immunology
- Inflammatory bowel disease
- Gut microbiota
- Fibre
- Prebiotic
Research Methodology
- Shotgun sequencing
- qPCR and ddPCR - bacterial enumeration and cytokine production
- Animal models of colitis
- Immunostaining
- Flow cytometry
- Human intervention studies
- Metaproteomics
Faculty
Faculty of Medicine