Genelle Healey

Project Description

Currently I am undertaking an animal model of inflammatory bowel disease study using Muc2 KO mice. These mice lack a mucus layer and therefore develop spontanous colitis by 12-16 weeks of age. We are feeding these mice either a fermentable fibre free or prebiotic enriched diet to determine what impact fibre has on the development of sponanteous colitis and understand the mechanisms of action involved.

Research Interests

  • Immunology
  • Inflammatory bowel disease
  • Gut microbiota
  • Fibre
  • Prebiotic

Research Methodology

  • Shotgun sequencing
  • qPCR and ddPCR - bacterial enumeration and cytokine production
  • Animal models of colitis
  • Immunostaining
  • Flow cytometry
  • Human intervention studies
  • Metaproteomics

Faculty

Faculty of Medicine