Project Description
We aim to determine whether an exclusive enteral formula containing fibre leads to lower disease severity, reduced inflammation and more beneficial gut microbiota changes when compared to standard exclusive enteral formula (which contains no fibre) and normal chow using mouse models of colitis.
We are also planning on conducting a study in pediatric Crohn's disease and ulcerative colitis patients to determine whether fiber containing exclusive enteral nutrition (EEN) enhances outcomes, and reduces relapse rates and the loss of beneficial gut microbiota when compared to standard EEN
Research Interests
- Immunology
- Inflammatory bowel disease
- Gut microbiota
Research Methodology
- Next-generation sequencing
- qPCR and ddPCR - bacterial enumeration and cytokine production
- Animal models of colitis
- Immunostaining
- Flow cytometry
- Human intervention studies
Faculty
Faculty of Medicine