Posting Expiry
We are pleased to announce a FAPESP postdoctoral fellowship opportunity within the thematic project "Plasticity and Functional Modulation of Intrinsically Disordered Proteins." The p53 protein plays a critical role in cell cycle control and apoptosis, and mutations in p53 allow the proliferation of abnormal cells, leading to cancer. Up to 50% of all human tumors contain p53 mutants. The main objective of the postdoctoral project is to study the effect of pathological mutations on the disordered tails of p53. The research will use computational methodology and be supervised by Prof. Vitor Leite (Institute of Chemistry, UNESP) and co-supervised by Prof. Guilherme A. P. de Oliveira (Institute of Medical Biochemistry, Federal University of Rio de Janeiro).
The specific project, “Energetic Landscape of the Intrinsically Disordered N- and C-terminal Tails of p53 and Their Impact on Demixing, Phase Separation, and Aggregation in Cancer,” aims to provide advanced training in computational methods, statistical mechanics, and bioinformatics. Within the broader context of the thematic project, it seeks to train early-career researchers, promoting comprehensive interdisciplinary development in Biological Physics and Biomolecular Sciences.
Requirements:
- Previous experience with molecular dynamics simulations (required).
- Knowledge in molecular biophysics and computational methods.
- Experience with disordered proteins, protein folding, and energy landscape theory will be a plus.
Application:
Interested candidates should send their curriculum vitae and motivation letter to Prof. Vitor Leite (vitor.leite@unesp.br) by June 30, 2025.