Research topic
Research Description
The death rate caused by liver cancer has exhibited an upward trend in recent decades. However, current therapeutic options are limited due to the lack of knowledge about the underlying mechanisms of liver cancer. Significantly, more than half of liver cancer cases exhibit mutations in genome structure regulators, which are crucial for controlling gene expression and cellular differentiation. However, the mechanisms by which these changes drive liver cancer are not fully understood. My proposed research aims to investigate how the highly mutated gene, known as Lysine Methyl Transferases 2d (KMT2d), influences liver development and induces cancer using mice and organ models that mimic human livers. By studying the interaction partners of KMT2d, including transcription factors, I expect to gain comprehensive insights into its role in the liver formation and health. My study will advance our understanding of liver developmental biology and provide potential therapeutic avenues for liver cancer.
Why did you decide to pursue a postdoctoral fellowship at UBC? Did you consider other opportunities?
UBC is a world-class research institution that offers a supportive environment and expertise in genomic, epigenomic, and advanced bioinformatic methodologies. The UBC's commitment to interdepartmental and interinstitutional collaborations aligns perfectly with my goal of conducting comprehensive research on liver development. Additionally, the UBC provides valuable resources for professional career development, making it an ideal choice for my postdoctoral fellowship. It was my top choice given its outstanding reputation and the opportunities it offers for advancing my research and career.
What specifically attracted you to your research group?
My overarching goal is to become an independent principal investigator in an academic environment, focusing on research in mechanisms of liver development and diseases. Dr. Pamela Hoodless' laboratory is the most ideal for successfully completing my proposed research and achieving my career goal. Dr. Hoodless is a renowned scientist in the field of liver biology with a remarkable track record of exceptional research achievements. Moreover, the Hoodless laboratory possesses the expertise and state-of-the-art equipment crucial for my study. Lastly, Dr. Hoodless has a strong nationwide and international collaborative network, which would greatly enrich my research experience and broaden my scientific perspectives.
What advice do you have for new postdoctoral fellows?
I encourage new postdoctoral fellows to prioritize enhancing their writing skills, as effective communication in sharing research findings and engaging with peers and the broader scientific community is crucial. Moreover, the postdoctoral training experience presents a great opportunity for these fellows to further develop their leadership abilities through mentoring undergraduate and graduate students. Lastly, while the pursuit of research excellence remains paramount, it is equally vital for postdoctoral fellows to establish personal boundaries and dedicate time to self-care, thereby safeguarding against burnout.
What do you like to do for fun?
One of my favorite hobbies is Latin (Salsa and Bachata) dancing. It's a wonderful escape from the daily routine and brings together my passion for music, movement, and socializing. Dancing allows me to express myself and connect with others in a unique and captivating way.
What is the most enjoyable aspect of your postdoctoral fellowship?
During my postdoctoral fellowship, I have been fortunate to have ample support from my supervisor and funding sources. As a result, I have been able to participate in various workshops and conferences directly related to my research and career development. Being able to learn new knowledge and techniques has been incredibly rewarding. Attending these events has expanded my understanding of my field and provided valuable networking opportunities with other professionals. It's been exciting to stay up-to-date with the latest advancements and explore different perspectives through these engagements. I am grateful for the opportunities that my postdoctoral fellowship has provided for personal and professional growth.
What does receiving this award mean for your career?
The prestigious NSERC postdoctoral fellowship award allows me to focus on the proposed research by securing financial stability and drive the project in directions that will boost my career. It also significantly supports my professional development towards becoming an independent principal investigator, while further enhancing my skills and expertise. Moreover, it propels me closer to achieving my personal and professional goals, opening new avenues for future collaborations and fostering exponential growth opportunities.