Faculty of Medicine

Organ transplantation is a life-saving therapy for end-stage organ failure. Ischemia–reperfusion injury that leads to delayed graft function (DGF) and immune-mediated rejection are unmet challenges. The key to success in organ transplantation is to suppress the immune system and prevent rejection. Current treatment using immunosuppressive drugs has reduced the incidents of rejection; however, such global immunosuppression leads to severe side effects. Thus, new approaches are needed for improved graft survival.

Develop and apply new algorithms and machine learning methods for analyzing proteomic data and integrating multi-omics data (including genomics, transcriptome, other MS data like metabolomics and lipidomics, and metagnomics).
 

The ability for cancers to grow rapidly is in part due to the activation of certain proteins exposed on the membrane of cancer cells. The goal of immunotherapy is to target cells exposing these proteins while sparing normal, healthy cells. Among immunotherapy strategies, chimeric antigen receptor (CAR) T cell therapy exploits the patient’s own immune system to fight cancer cells. CAR T cell therapy has achieved promising results in pediatric blood cancers; however, this strategy has not been tested extensively in pediatric brain tumors such as medulloblastoma.

Charaterization of brain and retinal degenrations in Alzhemier's disease.
Tear fluids microRNAs in Assessing Alzheimer's disease.
Understand the exsisting clerance mechsnisms.
Neuroprotective effects of natural products.

Deciphering the role of granzyme B in choroidal neovascularization and subretinal fibrosis of neovascular age-related macular degeneration

My current research focuses on developing new diagnostic assays to aid in the early and accurate diagnosis of dementia. More broadly, I am interested in the contribution of early-life environmental factors (e.g., sickness, socio-economic statues, diet) in the development of neurodegenerative disease.