Gastrointestinal Pathologies

Genelle Healey

We aim to determine whether an exclusive enteral formula containing fibre leads to enhanced mucosal healing, reduced inflammation and more beneficial gut microbiota changes when compared to standard exclusive enteral formula (which contains no fibre) and normal chow using mouse models of colitis.  

Joannie Allaire

Patients with Inflammatory Bowel Disease (IBD) suffer exaggerated gut inflammation that often leads to an imbalance in the types of microbes found in their intestines. Thus IBD patients often display a loss of typically beneficial bacteria and an overgrowth of potentially dangerous bacteria. In healthy individuals, such responses are typically prevented by the expression of SIGIRR, a protein expressed by the epithelial cells that line the gut. SIGIRR plays a key role in suppressing responses that drive inflammation and kill bacteria.