Gene Regulation and Expression

Jennifer Rowland

Bacteria that cause disease use a wide variety of mechanisms to control their environment. In particular, bacteria that invade host cells and use them to replicate, such as the bacterium responsible for the majority of food-poisoning cases in Canada, Salmonella, are adept at modifying their environments. Salmonella must subvert the routines of immune cells of the host that would normally prevent infection. As part of this subversion, salmonella alters normal host cell signaling pathways, preventing immune functions.