I am working on strategies for stroke recovery based on neuronal activity. Stroke results in an irreversible primary injury, and a salvageable secondary injury in the surrounding tissue. My research aims to develop therapies to target this secondary injury in animal models of stroke. We are developing automated systems to assess various strategies for stroke recovery. Our current setup consists of a high-tech home cage housing up to 10 mice. The cage has several modules for automated functional brain imaging, animal weighing, reward-based learning, and robot-assisted motor recovery.
With over 44 million affected persons and an economic burden of over $600 billion Alzheimer’s Disease (AD) is the leading cause of senile dementia. Beyond the beta-amyloid (Ab) plaques and neurofibrillary tangles that define AD, 60-90% of AD brains have cerebral small vessel disease, including cerebral amyloid angiopathy (CAA) and microvascular degeneration.