- Dissecting molecular basis of pancreatic insulin-secreting beta cell dysfunction and destruction during the development of type 1 and type 2 diabetes.
- Identifying and validating biomarkers of beta cell dysfunction to predict and manage type 1 diabetes.
The main objective of my current research project is to investigate sex-based differences in diaphragmatic fatigue (DF) after a pressure-threshold loading protocol under normoxic, acute hypoxic and hyperoxic conditions. In addition, to verify if there is a correlation between the magnitude of diaphragmatic fatigue, work of breathing, and oxygen availability. It is well acknowledged that women have smaller airways relative to lung size compared to men; this predisposes women to greater mechanical constraints during respiratory high-demand activities (i.e.
My current research in the Altshuler Lab addresses gaps in our understanding of how the nervous and muscular systems can actuate and control complex motor behaviors. The avian wing contains ~19 intrinsic muscles and ~11 skeletal elements that are controlled to actively change wing shape, an ability termed “wing morphing”. Previous research on avian wing morphing has produced only limited understanding of how birds reshape their wings, focusing more on basic kinematic and aerodynamic descriptions.