The Entelligence Young Investigator Program

The deadline for this funding opportunity as passed. Please check back for the next application cycle. 

The ENTELLIGENCE Young Investigator Program is a US-based research program consistent with Actelion Pharmaceutical US, Inc.’s commitment to basic science, translational, and clinical research in the area of pulmonary vascular disease.

Young investigators at universities and research institutes in the United States and Canada with innovative projects and promising careers in pulmonary vascular disease have been supported by the ENTELLIGENCE program since 2005.

Individual grants of up to $100,000 are provided to qualified investigators to conduct research on the basic mechanisms and/or vascular biology of pulmonary vascular disease via a 12-month mentored grant. Grants are awarded by the ENTELLIGENCE Steering Committee and based on scientific merit, originality, feasibility, and applicability to the diagnosis and treatment of pulmonary hypertension.



Application Procedures

To apply, please fill out the application forms here.

Eligibility Summary

1. Applicants must be a United States (US) citizen, a permanent US resident, a Canadian citizen, or permanent Canadian resident at time of LOI submission. Applicants with nonimmigrant visas are not eligible to apply.

2. Applicants must be engaged principally in basic science, translation and/or clinical research, with a proposal aimed at understanding the pathways and pathophysiology of pulmonary vascular disease.

3. Applicants must have no more than 5 years of experience beyond his/her first faculty appointment at the start of the award (as of July 1st of the award year). [Prior appointments in a different area of research will require an explanation in the application, to avoid being counted as part of the “5 years of experience” criteria.]

4. Significant funding from any of the following grants or awards will disqualify the applicant: · US: NIH-R01, NIH-P01 project, VA Merit Review Award, NSF, DOD or equivalent, NIH-K awards, AHA-SDG, NSA Career Development Award, VA Career Development Award or equivalent · Canada: CIHR (Project grant), Heart and Stroke Foundation Grant (National Award)

5. Applicants must have completed their primary research training (PhD or sub-specialty fellowship training) by July 1st of award year. Applicants can be a junior faculty member (up to and including the rank of Assistant Professor), postdoctoral scholar, doctoral candidate or fellow (last year and finishing by July 1st of the award year).

6. Applicants must have a firm commitment from their home institution for mentored career development. (The applicant’s mentor should be involved in overseeing the means for adequate funding to support necessary research, ensuring protected time for the applicant to complete his/her research and to investigate career development, and helping the applicant obtain a firm commitment from the applicant’s institution. This must be carefully addressed in the mentor's letter).

7. Applicants may not be an employee of a commercial entity (eg, pharmaceutical company).

8. Applicants may submit only one ENTELLIGENCE research proposal per application round.

9. Past winners will not be allowed to submit another LOI during the subsequent award cycle. The Steering Committee adheres strictly to the above eligibility requirements. Particular scrutiny is given to the young investigator status of the application. If the applicant has had extended training, and/or multiple degrees, and/or multiple fellowships, and/or current or prior research awards but the mentor believes that the applicant is still a young investigator early in his/her career, the mentor should consider justification in the introductory statement of the mentor letter. It should be clear that the applicant is at the early phase of an academic career with a strong interest in pulmonary hypertension.

Criteria for eligible projects

1. Site: University or research institute; US or Canada

 2. Length and Budget: The project must be achievable within the time frame (1 year) and budget allocation ($100,000) of the ENTELLIGENCE program. Additional funding sources are acceptable and must be clearly indicated in the proposal.

 3. Focus: Develop a better understanding of/approach to disorders of pulmonary vascular biology. Note: bridge funding, therapeutic drug trials, or registry trials will not be funded.

4. Research type: Basic science, translation, and/or clinical

5. Mentor: Applicant must be supervised by an appropriate mentor Mentors must ensure the means for adequate funding to support necessary research and must see the project through to successful completion. Principal investigators must be given protected time to complete their research and this research should be carried out mainly by the awardee; mentors should have only an advisory role in the project. This must be carefully addressed in the mentor's letter.

6. Co-investigators: Co-investigators may be included; however, the specific role of each coinvestigator and justification will be carefully evaluated.

Grant funds cannot be awarded to principal investigators whose salaries are largely derived from commercial organizations in the pharmaceutical or allied industries. However, research support from commercial organizations is allowed.

Grant funds are not institution-specific and are awarded to fund specific projects headed by the principal investigator. In the event that the principal investigator changes institutions during the course of his or her research project, the ENTELLIGENCE Young Investigator Award Program may fund remaining unfunded grant amounts to the principal investigator only if the young investigator can adequately establish to the ENTELLIGENCE Steering Committee that the project can be properly completed as planned at the young investigator’s new institution. Unfunded grant amounts will NOT be distributed to a different principal investigator at the young investigator’s old institution.

Award Ceremony: New award winners must attend the ENTELLIGENCE Award Ceremony held at the annual ATS meeting in May of the year the award is to begin; travel and one-night hotel stay will be provided. Mentors are encouraged to attend; their travel and one-night hotel stay will also be provided.

Prior award winners will be required to present the progress/findings of their research in writing. If a data embargo prevents the data from being presented, the study design and objectives will be required to be presented at a return visit the following year to publicize data results and conclusion.

Annual Value

up to $100,000