Career Opportunities

Research Interests: Carcinogenesis, Cellular Differentiation, Epigenomics, Leukemia, Molecular Genetics

Research Interests: Microbiology, Biological and Biochemical Mechanisms, Functional and Structural Proteomics, Microbial Ultrastructure, Cryo-electron tomography and Structural Biology, Bacterial Physiology, Microbial Diversity, Secretion systems and Mechanisms of pathogenesis, Novel bacterial phyla

Research Interests: Biological and Biochemical Mechanisms, Biomass, Carbohydrates, Cellulose, Chemical Synthesis and Catalysis, Enzymes, Microbiota, Plant cell walls, Polysaccharides

Research Interests: Adaptation, Crops, Invasive plants, Plant evolutionary biology, Speciation, Weeds

Potential project areas:

Adaptation, Speciation, Evolution of Crops and Weeds, Bioinformatics

Research Interests: Arts, Literature and Subjectivity, Comparative Literature, Creative Writing, French Literature (1945 to the present), Québec and French-Canadian Literature and Culture, Spatial Poetics, Visual Culture

Research Interests: CRISPR/Cas, Diabetes, Human pluripotent stem cells, Transcriptional regulation, ß-cell biology, ß-cell development

Potential project areas:

Research in the Lynn lab is targeted at understanding the insulin-producing pancreatic β-cell, how it fails during diabetes mellitus and how we can make surrogate cells to cure diabetes. We use a variety of models to study the regulatory pathways important for embryonic β-cell genesis and function. The current focus of research in the lab is understanding how DNA-binding transcription factors regulate β-cell formation and function, how they are reguated post-translationally and how they prevent β-cell dysfunction and diabetes. We currently have positions available for graduate students and postdoctoral scholars interested in studying the regulation of pancreatic β-cell development and function. Please contact me personally by e-mail with a cover letter outlining your interests, why you would like to join my lab, and please include your vita. Experience in cell and developmental biology, molecular biology or stem cell biology is preferred. More important are curiosity and passion about stem and developmental biology, and a talent for independent research, supported by a strong publication record.

Research Interests: Chromatin Biology, Epigenetics, Molecular Biology, Social Epigenetics

Research Interests: Partial differential equations, mathematical physics

Research Interests: Stroke rehabilitation, Implementation science, Wearable sensors, Recovery of walking after stroke, Recovery of upper extremity function after stroke

Research Interests: Asthma, Immune System, Immunodeficiencies, Microbiome cohort studies, Precision medicine, Primary immune deficiencies

Potential project areas:

Genetics of Susceptibility to Childhood Infection Until very recently, clinical immunologists have focused most attention on patients with a ‘noisy clinical phenotype’—multiple, severe and recurrent infections. Indeed, the origin of primary immunodeficiencies is generally attributed to Bruton’s 1952 description of X-linked agammaglobulinemia in a boy whose repeated pneumococcal infections demanded clinical attention. Today, enhanced understanding of human immunity combined with ever more sophisticated tools to dissect the immune response have allowed clinical immunologists to look beyond these "noisy", severely immunocompromised patients to individuals with less obvious immune defects. We have entered the era of "subtle" primary immunodeficiencies that will begin to precipitate a fundamental change and expansion of the focus of clinical immunologists. My lab is involved in searching for subtle genetic immune defects in apparently healthy children who have serious immunological disorders. This journey towards subtlety is anticipated to translate into better care for our patients through improved diagnosis, combined with tailored treatment and targeted prophylaxis. Canadian Healthy Infant Longitudinal Development (CHILD) Study Over the past 30 years there has been an increasing concern about the effects of environment on health. In particular, since infants spend the majority of their time indoors, there is intense interest in the impact indoor pollution has on the health of our children. Our indoor environment has become a public health priority as growing evidence suggests that unseen environmental contaminants in our living spaces may have important effects on children's health and development. The Canadian Healthy Infant Longitudinal Development (CHILD) Study is a multicentre, multidisciplinary, longitudinal, population-based birth-cohort study of 5,000 children enrolled "pre-birth" and followed for five years (www.canadianchildstudy.ca). The main purpose of this study is to determine what aspects of the environment interact with genetic factors to affect children’s health and development. I am a co-principal investigator for the CHILD study and I lead the Vancouver study site. Innate Immunity and Lung Inflammation in Cystic Fibrosis Cystic fibrosis (CF) is the most common, deadly genetic disease affecting young Canadians. Even today, only half of the people living with CF will survive beyond their mid-thirties. New treatments for CF are critically needed. Lung disease is the major life-limiting factor for people living with CF. Lung injury in CF occurs through a vicious cycle of airway blockage, infection and inflammation. Current CF treatments rely upon physiotherapy to reduce airway blockage and antibiotics to treat the infections, but these treatments do not specifically deal with inflammation. New treatments to simultaneously target airway inflammation are likely to provide substantial additional benefits in improving the quality and length of life for those with CF. Through synergistic studies harnessing the power of cell biology, chemistry and functional genomics, we are working to identify optimal "druggable" targets responsible for CF airway inflammation and to discover novel anti-inflammatory drugs. Ultimately, these experiments are designed to develop new therapies for safely reducing lung inflammation and improving the quality and length of life of people with CF.