Career Opportunities

Research Interests: Aging, Cell Biology, Neurodegenerative diseases, Proteasome, Protein Degradation, Protein Folding, Proteomics, Proteostasis, Ubiquitin, Yeast Genetics

Potential project areas:

The main lab focus is protein quality control and how misfolded proteins are triaged within the cell. In the next years, we want to establish several new projects and here are some examples:
- Identification of protein quality control pathways mediating rare genetic diseases in human.
- Reconstitution of the quality control machinery in vitro to better understand the molecular mechanism.
- Characterization of the Nedd4/Rsp5 quality control pathway in mammalian cells.
- Development of new proteomics approaches to determine client repertoires of chaperone proteins.
- Characterization of the formation of heat stress granules.
- Characterization of changes in the protein homeostasis network upon aging

Research Interests: Agri-food Transformation Products, Microbiology, Bioactive Molecules, Food Microbiology, Food Safety

Research Interests: American Literature, Postmodernism

Research Interests: Dual organism molecular interaction (fungal spores & human airway epithelium), Early and late reactions in allergic asthma and rhinitis, Diagnostics of acute heart rejection post-transplantation, Neonatal vaccine immunogenicity, Systems biology, biomarkers & bioinformatics, Rheumatic fever and heart disease, COVID-19

Research Interests: emergency radiology; ways to develop faster, safer, and more sensitive methods for diagnosing patients in the acute care setting; ultra low dose techniques in the acute setting, dual energy CT in the acute setting, polytrauma imaging, brain perfusion in trauma and role of MRI in the acute setting.

Potential project areas:

Emergency/Trauma Imaging, Computed Tomography, Machine Learning, Healthcare Applications

Research Interests: Colonial Legal History, Critical Theory, Oceans and Maritime Worlds, Philosophy, History and Comparative Studies, Race and Racism, Time and Temporality

Research Interests: Climate change, Polar climate, Isotope geochemistry, Data analysis, inverse modeling, Paleoclimate

Research Interests: Community Health / Public Health, Behavioral medicine, Exercise psychology, Mental health, Physical activity and public health, Physical activity interventions

Potential project areas:

Physical activity and public health - intervention development and evaluation

Research Interests: Asthma, Immune System, Immunodeficiencies, Microbiome cohort studies, Precision medicine, Primary immune deficiencies

Potential project areas:

Genetics of Susceptibility to Childhood Infection Until very recently, clinical immunologists have focused most attention on patients with a ‘noisy clinical phenotype’—multiple, severe and recurrent infections. Indeed, the origin of primary immunodeficiencies is generally attributed to Bruton’s 1952 description of X-linked agammaglobulinemia in a boy whose repeated pneumococcal infections demanded clinical attention. Today, enhanced understanding of human immunity combined with ever more sophisticated tools to dissect the immune response have allowed clinical immunologists to look beyond these "noisy", severely immunocompromised patients to individuals with less obvious immune defects. We have entered the era of "subtle" primary immunodeficiencies that will begin to precipitate a fundamental change and expansion of the focus of clinical immunologists. My lab is involved in searching for subtle genetic immune defects in apparently healthy children who have serious immunological disorders. This journey towards subtlety is anticipated to translate into better care for our patients through improved diagnosis, combined with tailored treatment and targeted prophylaxis. Canadian Healthy Infant Longitudinal Development (CHILD) Study Over the past 30 years there has been an increasing concern about the effects of environment on health. In particular, since infants spend the majority of their time indoors, there is intense interest in the impact indoor pollution has on the health of our children. Our indoor environment has become a public health priority as growing evidence suggests that unseen environmental contaminants in our living spaces may have important effects on children's health and development. The Canadian Healthy Infant Longitudinal Development (CHILD) Study is a multicentre, multidisciplinary, longitudinal, population-based birth-cohort study of 5,000 children enrolled "pre-birth" and followed for five years (www.canadianchildstudy.ca). The main purpose of this study is to determine what aspects of the environment interact with genetic factors to affect children’s health and development. I am a co-principal investigator for the CHILD study and I lead the Vancouver study site. Innate Immunity and Lung Inflammation in Cystic Fibrosis Cystic fibrosis (CF) is the most common, deadly genetic disease affecting young Canadians. Even today, only half of the people living with CF will survive beyond their mid-thirties. New treatments for CF are critically needed. Lung disease is the major life-limiting factor for people living with CF. Lung injury in CF occurs through a vicious cycle of airway blockage, infection and inflammation. Current CF treatments rely upon physiotherapy to reduce airway blockage and antibiotics to treat the infections, but these treatments do not specifically deal with inflammation. New treatments to simultaneously target airway inflammation are likely to provide substantial additional benefits in improving the quality and length of life for those with CF. Through synergistic studies harnessing the power of cell biology, chemistry and functional genomics, we are working to identify optimal "druggable" targets responsible for CF airway inflammation and to discover novel anti-inflammatory drugs. Ultimately, these experiments are designed to develop new therapies for safely reducing lung inflammation and improving the quality and length of life of people with CF.

Research Interests: Digital health, Mobile health (mHealth), Precision Public Health, Patient-centered care, Global Health, Infectious Diseases

Potential project areas:

Global digital health for patient engagement in care and virtual care. Work in Canada, Africa and globally. Quantitative and qualitative studies, implementation research, data science, and digital health policy and ethics. Especially among scaling interventions to benefit vulnerable populations and health equity.