Nathaniel Sharp, postdoctoral fellow with the Biodiversity Research Centre, is one of this year’s Banting Postdoctoral Fellows. Originally from Toronto, Nathaniel started his postdoc work at UBC in 2014, working with Sally Otto and Michael Whitlock, at the Department of Zoology’s Biodiversity Research Centre.
Sex and outcrossing are fundamentally important modes of reproduction, and there is considerable variation in these traits among species. There is also variation in the number of copies of the genome contained in each cell, where many organisms have two copies of the genome and many others have just one. Evolutionary transitions between reproductive modes are expected to affect numerous dimensions of biological diversity, including sexual dimorphism, genetic variation for fitness, molecular genetic variation, genetic load, inbreeding depression, transposable element dynamics, sexually antagonistic variation, and sexual selection. Comparative approaches have provided insight into the long-term consequences of reproductive system evolution, and there is a long history of theoretical investigations that have generated predictions in this area. However, very few experiments have been performed to study the initial stages of these transitions. I am studying the early evolutionary consequences of reproductive system transitions by manipulating the degree of sexuality of the budding yeast, Saccharomyces cerevisiae. Through experimental evolution in this genetic model organism I am examining the effects of reproductive mode on fundamental aspects of the spontaneous mutation process, the evolution of genomes, and life history strategies. This work will test controversial hypotheses concerning the origins of reproductive diversity.
Why did you decide to pursue a postdoctoral fellowship at UBC? Did you consider other opportunities?
UBC is one of the foremost institutions for ecology and evolutionary biology in the world. The Department of Zoology and the Biodiversity Research Centre are highly interactive and multi-disciplinary groups, with many colleagues who share my interest in mating systems, evolutionary genetics and genomics. In particular, my supervisors have world-class reputations in evolutionary biology. I’ll also benefit from the facilities for genome sequencing, flow cytometry, and computing.